Thelma Therezinha Goncalez, MD, PhD
- Associate Clinical Investigator, BSRI
270 Masonic Ave.
San Francisco, CA 94118
Phone: (415) 749-6685
Fax: (415) 567-5899
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curriculum vitae [pdf file]
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- M.D., Medical School Sao Jose do Rio Preto - Sao Paulo BRAZIL
- Ph.D., Sao Paulo Medical School - Sao Paulo University BRAZIL
- Epidemiology donor and recipient studies focusing on transfusion transmitted diseases
- Epidemiology study focusing on HIV positive donors
- Behavioral Donor Studies: Test-Seeking, Motivation and Sexual Behaviors
- Blood transfusion and blood utilization and patient outcomes
Complete one or more paragraphs for each area of study and/or interest.
Principal Investigator of NIH R01HL108704-01 Clinical Trial “Improving Blood Safety and HIV Testing in Brazil: a randomized Controlled Trial"
The study is an randomized controlled trial (RCT) to test the hypotheses that the offering of voluntary client-centered HIV counseling and testing (HCT) at the time of presentation for blood donation will provide rigorous evidence for two beneficial outcomes: 1) improving the safety of the blood supply as measured by reduced HSV-2, HIV and other transfusion-transmissible infection (TTI) among donations, and 2) increasing the uptake of receiving test results, counseling and referrals. This study is taking place at FPSangue/Hemocentro de Sao Paulo, Brazil.
NIH/NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III) International (Brazil)
Compilation of extensive blood donor/recipient data and specimens as stipulated in the RFP; we will conduct 4 research projects on critical transfusion medicine issues in Brazil.
REDS-III “The effectiveness of donor notification, HIV counseling, and linkage of HIV positive donors to health care in Brazil”.
In this protocol we will conduct a study with three aims. The first aim of the project will analyze the proportion of donors who are successfully notified of infection results from blood donation testing. In this aim we will expand the focus to include all infections that blood centers in Brazil test donations for because donor follow-up with blood centers is poor regardless of the infection type, but differences in notification by infection are unknown. The two other aims will assess the effectiveness of HIV notification and counseling. In the second aim we will interview a cohort of HIV positive donors to evaluate their follow-up activities with regard to HIV infection treatment and infection transmission prevention behavior after notification by the blood center, using an audio computer-assisted structured interview. The sample for this part of the project will be former donors who have already participated in REDS-II and REDS-III HIV case interviews during the interval of 2008 – 2013. The goals are to understand what, if any, behavior changes were adopted to reduce further transmission of HIV and to obtain information on HIV disease progression and medical care. The third aim is to use HIV positive blood donors as key informants by inquiring about ways we can improve the disclosure of HIV risks in donors during eligibility assessment and also to better understand the motivating factors that drive high-risk persons to donate blood. A secondary aim of the project is to collect blood specimens, creating a longitudinal set of specimens from participants, for potential future testing of HIV related biomarkers. Results of these aims may help to better integrate blood centers within the context of broader HIV testing, counseling and treatment sites in Brazil.
Prevalence, Incidence, Epidemiology and Molecular Variants of HIV in Blood Donors in Brazil: Analysis of viral characteristics and risk factors in HIV-infected donors.
This study is taking place at the 4 blood centers in Brazil at FPS/Hemocentro Sao Paulo in Sao Paulo; Hemope/ Recife, Pernambuco; Hemorio/Rio de Janeiro and Hemominas/Belo Horizonte, Minas Gerais. This study will determine risk factors associated with HIV infection, HIV subtype, and drug resistance profile among HIV positive donors. The primary modification to this study as compared to the previous REDS-II HIV case control study is that we have dropped the enrollment and interviewing of HIV negative donors. The REDS-III molecular surveillance study will focus on enrolling HIV positive cases only. Blood samples for molecular surveillance and risk factor interviews using the Audio Computer Assisted Self-Interview (ACASI) modality will be continued.
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