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Mars StoneMars Stone, PhD

Current Positions:

  • Staff Scientist II, BSRI
  • Staff Scientist, Department of Laboratory Medicine, UCSF

Contact Information:
270 Masonic Ave.
San Francisco, CA 94118
Phone: (415) 354-1389
Fax: (415) 775- 3859
Email: mstone@bloodsystems.org

 

 

 

Download a scientific summary [pdf file]

Download a curriculum vitae [pdf file]

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Education:

  • Ph.D. Microbiology, University of California, Davis 2010. Focus in Molecular Virology, primate model of human disease.
  • B.S. Molecular Biology, University of San Francisco 1999. Minor in Biochemistry.

Training/Appointments:

  • 2010-2011 - Post Doctoral Fellow, Department of Virology and Immunology, Center for Comparative Medicine University of California, Davis. Characterization of transmitted SIV founder populations in rhesus macaques. Use of integration inhibitors for the detection of low-level active replication.
  • 2003-2010 - Post Graduate Researcher, California National Primate Research Center, University of California, Davis. Relationship between viral variation and replication after challenge in vaccinated rhesus macaques. Relative infectivity of plasma virus analogous to human blood supply safety.
  • 2003 - Teaching Assistant School of Biological Sciences, University of California, Davis
  • 1999-2002 - Staff Research Associate, Laboratory of Dr. Jay Levy, University of California, San Francisco. Characterization of anti-HIV factor expressed by CD8+ T-cells.

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Research Interests:

  • HIV Infection and latency
  • HIV Prevalence and Incidence Screening
  • Transfusion transmitted infections and pathologies

Current research

REDS-III

Dr. Stone’s group performs key Central Lab functions for the Recipient Epidemiology and Donor Evaluation Study-III. This NHLBI program is directed at ensuring safe and effective blood banking and transfusion medicine practices both domestically and internationally, including countries seriously affected by the AIDS epidemic and have critical challenges in blood safety and supply. Pilot studies informing the development of REDSIII processes and protocols will also be pursued by Dr. Stone’s lab.

MARS

The Mechanism and Repository Study (MARS) is a large multicenter study of critically ill cardiac surgery patients examining potential mechanisms associated with the RBC storage lesion and adverse outcomes. Dr. Stone’s group manages and processes samples drawn remotely from participating cardiac surgery centers.

HCV infection in intravenous drug users

The UCSF VIP study is a Phase I/II Study to assess safety, efficacy and immunogenicity of a new Hepatitis C prophylactic vaccine based on Sequential Use of AdCh3NSmut1 and MVANSmut in active injection drug users at high risk for hepatitis C. Blood samples drawn from participants are processed and managed by Dr. Stone’s group.

T-cell exhaustion in latent HIV infection

Persistence of HIV is hypothesized to be the result of anergy and T cell exhaustion potentially responsible for attenuated HIV expression in chronically and latently infected CD4+ cells. Dr. Stone is collaborating to characterize the evolution of T-cell exhaustion during HIV therapy to determine whether “tolerized” T-cells are enriched for provirus in the absence of viral replication and explore potential interventions to induce virus expression from latent cells and stimulate immune and pharmacological clearance of HIV reservoirs.

PUBLICATIONS

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