Mars Stone, PhD
Download a scientific summary [pdf file]
Download a curriculum vitae [pdf file]
Dr. Stone’s group performs key Central Lab functions for the Recipient Epidemiology and Donor Evaluation Study-III. This NHLBI program is directed at ensuring safe and effective blood banking and transfusion medicine practices both domestically and internationally, including countries seriously affected by the AIDS epidemic and have critical challenges in blood safety and supply. Pilot studies informing the development of REDSIII processes and protocols will also be pursued by Dr. Stone’s lab.
The Mechanism and Repository Study (MARS) is a large multicenter study of critically ill cardiac surgery patients examining potential mechanisms associated with the RBC storage lesion and adverse outcomes. Dr. Stone’s group manages and processes samples drawn remotely from participating cardiac surgery centers.
HCV infection in intravenous drug users
The UCSF VIP study is a Phase I/II Study to assess safety, efficacy and immunogenicity of a new Hepatitis C prophylactic vaccine based on Sequential Use of AdCh3NSmut1 and MVANSmut in active injection drug users at high risk for hepatitis C. Blood samples drawn from participants are processed and managed by Dr. Stone’s group.
T-cell exhaustion in latent HIV infection
Persistence of HIV is hypothesized to be the result of anergy and T cell exhaustion potentially responsible for attenuated HIV expression in chronically and latently infected CD4+ cells. Dr. Stone is collaborating to characterize the evolution of T-cell exhaustion during HIV therapy to determine whether “tolerized” T-cells are enriched for provirus in the absence of viral replication and explore potential interventions to induce virus expression from latent cells and stimulate immune and pharmacological clearance of HIV reservoirs.